Chronically elevated levels of the stress hormone cortisol block the beneficial effects of testosterone.
As we know, intergenerational testosterone levels in American men are dropping so low that a 30 year old man today has the T level that a 60 year old man had twenty years ago.
The cortisol-testosterone feedback axis may be to blame. Something about modernity causes massively elevated stress and anxiety in people, which in men contributes to their docility and decreasing T and in women to their self-destructive BPD mania and depression.
https://news.utexas.edu/2010/09/27/stress-hormone-blocks-testosterones-effects-study-shows/
